Impaired Innate Immune System and Diseases.

Innate Immune System and Preeclampsia

Normal pregnancy is considered as a Th2 type immunological state that favors an immune-tolerance environment in order to prevent fetal rejection. Preeclampsia (PE) has been classically described as a Th1/Th2 imbalance; however, the Th1/Th2 paradigm has proven insufficient to fully explain the functional and molecular changes observed during normal/pathological pregnancies. Recent studies have e...

The innate immune system

The innate immune system ; is an important subsystem of the overall immune response system that comprises the cells and mechanisms that defend the host from infection by other organisms. The cells of the innate system recognize and respond to pathogens in a generic way, but, unlike the adaptive immune system, the system does not confer long-lasting or protective immunity to the host. Innate imm...

Preface: Innate immune sensors in joint diseases.

Modelling the Innate Immune System

The Human Immune System (HIS) is a complex network composed of specialized cells, tissues, and organs that is responsible for protecting the organism against diseases caused by distinct pathogenic agents, such as viruses, bacteria and other parasites. The first line of defence against pathogenic agents consists of physical barriers of skin and the mucous membranes. If the pathogenic agents brea...

FPRs: linking innate immune system and fibrosis

Fibrosis is a deregulated and uncontrolled repair process that recapitulates features of embryonic development and normal wound healing. The inappropriate repair by connective tissue, characterized by an excessive deposition of collagen and other extracellular matrix components, is now known as an important feature of many chronic diseases, including myocardial infarction, glomerulosclerosis, i...